In the scheme of things whether or not you unpack your suitcase or work out of it is not the most crucial decision in the world that you will have to face in 2020 or beyond.
Some folks only unpack when they are staying in one place for three days or more.
Others find that using cubes keep things organized, and they can be removed from a suitcase and easily stacked.
Travelers say that unpacking makes them feel like they are making a temporary space more like home. It relaxes them in unfamilar surroundings.
Whatever your personality and style of travel, it all depends on your own level of comfort. I can't help you out here. (PS. I don't unpack).